There are many companies that promote various pills, elixirs, sprays, or creams that are claimed to contain useful amounts of HGH ; they claim that these products are actually taken up by the body through topical, oral, sublingual or nasal administration.

  One should be skeptical of such claims, as none of the published benefits of injected HGH have been objectively measured with oral tablets, capsules, or sprays.

HGH, from any other source, even from other animals, simply does not work in humans. Similar animal molecules have been shown to be species-specific and unable to mimic the effect of the human molecule; and there is absolutely no naturally occurring plant source of HGH . 

The Food and Drug Administration (FDA) licenses and oversees companies that manufacture HGH . They must register and verify their methods and product regarding uniformity of quality, bioavailability, safety, and demonstrated effectiveness. 

This large protein molecule is unable to penetrate intact membranes to any significant degree, making any spray or oral use of HGH almost completely a waste. The technology to make HGH is patented by large pharmaceutical companies and is restricted by law to their use. 

It is an expensive manufacturing process, making waste prohibitively expensive. HGH may only be administered via injection by prescription under the supervision of a licensed physician through a licensed clinic or pharmacy. 

Given the above requirements, there are several concerns that arise regarding the claims made by non-FDA approved companies that offer HGH products in oral or spray forms:

1. As stated above there are only a few companies approved by the FDA to manufacture HGH . Because of the patent parameters, manufacturing HGH is complex and extremely expensive. Any claim that a product contains HGH would, by federal law, require its production be verified, overseen, and approved by the FDA to meet its standards for quality and content. 

This creates a double bind for the purveyors of these oral and other form "HGH " products, because if they do contain any significant amount of HGH , it would be illegal to provide it without a prescription, exact content disclosure, or origin of production. 

The fact that these products do not have to meet the accepted oversight and dispensing standards would indicate that they do not actually contain any significant amount of HGH.

2. Molecules as large as HGH cannot be absorbed into the body across skin or mucous membranes. Even insulin, a molecule only half the size of HGH , and of similar type and construction, cannot be absorbed in this manner. Given this limitation, HGH is digested, or broken down into simpler compounds if it is not injected. 

Any claim that it can be absorbed in the oral mucosa and then transported to the Pituitary Gland, is nonsense, as HGH has no beneficial effect at the pituitary gland. The pituitary gland is the normal source of HGH in young adults. The pituitary releases HGH into the circulation so that it can have its effects elsewhere. 

Any claim that stimulating dose works by being absorbed into the feedback system of the Pituitary Gland, is total nonsense, meant to deceive scientifically unsophisticated consumers.

3. There are no published physiologic studies that show any appreciable improvement in systemic hGH/IGF-1 levels when delivered orally or by spray. If it were currently possible, the FDA approved pharmaceutical companies that manufacture HGH (and for that matter insulin) would dearly love to use delivery methods other than injection.

4. Given the expense involved in the manufacture of actual HGH , even if it were to be able to be administered orally or topically, the cost of delivering the proper dose of HGH would be equivalent to the current injection solutions, which have proven very high bioavailability and well-demonstrated correlation between dose and subsequent level.

5. HGH is a very fragile molecule; it is dependant upon the retention of a precise complete amino acid sequence and three-dimensional structure, with some parts of the molecule necessarily linked to others. It works on cell receptors exactly like a key in a lock, so, even if the chemical formula remains the same, any change in shape blocks HGH activity. The cross-linkages break very easily and become unstable soon after dissolving in solution. When refrigerated, biological activity may be maintained for up to two weeks before it loses its function. 

Considered as a whole, claims that over the counter or direct-marketed products contain or provide alternate forms of HGH are taking unwarranted advantage of consumer hopes, trust, and lack of medical knowledge. 

Using authentic claims about the benefits of human Growth Hormone which is injected, furthermore, is highly misleading, as that is not what they are selling.

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